AustralieFrV1, Main, Exploration, bibRecord, 000D40

Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir in Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials.

Identifieur interne : 000D40 ( Main/Exploration ); précédent : 000D39; suivant : 000D41

Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir in Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials.

Auteurs : Ira M. Jacobson [États-Unis] ; Eric Lawitz [États-Unis] ; Edward J. Gane [Nouvelle-Zélande] ; Bernard E. Willems [Canada] ; Peter J. Ruane [États-Unis] ; Ronald G. Nahass [États-Unis] ; Sergio M. Borgia [Canada] ; Stephen D. Shafran [Canada] ; Kimberly A. Workowski [Géorgie (pays)] ; Brian Pearlman [Géorgie (pays)] ; Robert H. Hyland [États-Unis] ; Luisa M. Stamm [États-Unis] ; Evguenia Svarovskaia [États-Unis] ; Hadas Dvory-Sobol [États-Unis] ; Yanni Zhu [États-Unis] ; G Mani Subramanian [États-Unis] ; Diana M. Brainard [États-Unis] ; John G. Mchutchison [États-Unis] ; Norbert Br U [États-Unis] ; Thomas Berg [Allemagne] ; Kosh Agarwal [Royaume-Uni] ; Bal Raj Bhandari [États-Unis] ; Mitchell Davis [États-Unis] ; Jordan J. Feld [Canada] ; Gregory J. Dore [Australie] ; Catherine A M. Stedman [Nouvelle-Zélande] ; Alexander J. Thompson [Australie] ; Tarik Asselah [France] ; Stuart K. Roberts [Australie] ; Graham R. Foster [Royaume-Uni]

Source :

Gastroenterology [ 1528-0012 ] ; 2017.

RBID : pubmed:28390869

Descripteurs français

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Antiviral Agents (administration & dosage), Antiviral Agents (adverse effects), Antiviral Agents (therapeutic use), Carbamates (administration & dosage), Carbamates (adverse effects), Carbamates (therapeutic use), Drug Therapy, Combination, Female, Hepatitis C, Chronic (drug therapy), Heterocyclic Compounds, 4 or More Rings (administration & dosage), Heterocyclic Compounds, 4 or More Rings (adverse effects), Heterocyclic Compounds, 4 or More Rings (therapeutic use), Humans, Macrocyclic Compounds (administration & dosage), Macrocyclic Compounds (adverse effects), Macrocyclic Compounds (therapeutic use), Male, Middle Aged, Sofosbuvir (administration & dosage), Sofosbuvir (adverse effects), Sofosbuvir (therapeutic use), Sulfonamides (administration & dosage), Sulfonamides (adverse effects), Sulfonamides (therapeutic use), Sustained Virologic Response, Young Adult.
MESH :
- chemical , administration & dosage : Antiviral Agents, Carbamates, Heterocyclic Compounds, 4 or More Rings, Macrocyclic Compounds, Sofosbuvir, Sulfonamides.
- chemical , adverse effects : Antiviral Agents, Carbamates, Heterocyclic Compounds, 4 or More Rings, Macrocyclic Compounds, Sofosbuvir, Sulfonamides.
- chemical , therapeutic use : Antiviral Agents, Carbamates, Heterocyclic Compounds, 4 or More Rings, Macrocyclic Compounds, Sofosbuvir, Sulfonamides.
- drug therapy : Hepatitis C, Chronic.
- Adolescent, Adult, Aged, Aged, 80 and over, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Sustained Virologic Response, Young Adult.

Abstract

Patients with chronic hepatitis C virus (HCV) infection have high rates of sustained virologic response (SVR) after 12 weeks of treatment with the nucleotide polymerase inhibitor sofosbuvir combined with the NS5A inhibitor velpatasvir. We assessed the efficacy of 8 weeks of treatment with sofosbuvir and velpatasvir plus the pangenotypic NS3/4A protease inhibitor voxilaprevir (sofosbuvir-velpatasvir-voxilaprevir).

DOI: 10.1053/j.gastro.2017.03.047
PubMed: 28390869

Affiliations:

Allemagne, Australie, Canada, France, Géorgie (pays), Nouvelle-Zélande, Royaume-Uni, États-Unis
Angleterre, Berlin, Californie, Floride, Grand Londres, Louisiane, New Jersey, Texas, État de New York
Berlin, Londres

Le document en format XML

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<author><name sortKey="Ruane, Peter J" sort="Ruane, Peter J" uniqKey="Ruane P" first="Peter J" last="Ruane">Peter J. Ruane</name>
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<author><name sortKey="Nahass, Ronald G" sort="Nahass, Ronald G" uniqKey="Nahass R" first="Ronald G" last="Nahass">Ronald G. Nahass</name>
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<author><name sortKey="Borgia, Sergio M" sort="Borgia, Sergio M" uniqKey="Borgia S" first="Sergio M" last="Borgia">Sergio M. Borgia</name>
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<author><name sortKey="Shafran, Stephen D" sort="Shafran, Stephen D" uniqKey="Shafran S" first="Stephen D" last="Shafran">Stephen D. Shafran</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation>
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<wicri:noRegion>Alberta</wicri:noRegion>
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<author><name sortKey="Workowski, Kimberly A" sort="Workowski, Kimberly A" uniqKey="Workowski K" first="Kimberly A" last="Workowski">Kimberly A. Workowski</name>
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<wicri:noRegion>Atlanta</wicri:noRegion>
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<author><name sortKey="Pearlman, Brian" sort="Pearlman, Brian" uniqKey="Pearlman B" first="Brian" last="Pearlman">Brian Pearlman</name>
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<author><name sortKey="Hyland, Robert H" sort="Hyland, Robert H" uniqKey="Hyland R" first="Robert H" last="Hyland">Robert H. Hyland</name>
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<author><name sortKey="Stamm, Luisa M" sort="Stamm, Luisa M" uniqKey="Stamm L" first="Luisa M" last="Stamm">Luisa M. Stamm</name>
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<author><name sortKey="Svarovskaia, Evguenia" sort="Svarovskaia, Evguenia" uniqKey="Svarovskaia E" first="Evguenia" last="Svarovskaia">Evguenia Svarovskaia</name>
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<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dvory Sobol, Hadas" sort="Dvory Sobol, Hadas" uniqKey="Dvory Sobol H" first="Hadas" last="Dvory-Sobol">Hadas Dvory-Sobol</name>
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<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Inc, Foster City</wicri:cityArea>
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</author>
<author><name sortKey="Zhu, Yanni" sort="Zhu, Yanni" uniqKey="Zhu Y" first="Yanni" last="Zhu">Yanni Zhu</name>
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</placeName>
<wicri:cityArea>Gilead Sciences, Inc, Foster City</wicri:cityArea>
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</author>
<author><name sortKey="Subramanian, G Mani" sort="Subramanian, G Mani" uniqKey="Subramanian G" first="G Mani" last="Subramanian">G Mani Subramanian</name>
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<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Inc, Foster City</wicri:cityArea>
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</author>
<author><name sortKey="Brainard, Diana M" sort="Brainard, Diana M" uniqKey="Brainard D" first="Diana M" last="Brainard">Diana M. Brainard</name>
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<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mchutchison, John G" sort="Mchutchison, John G" uniqKey="Mchutchison J" first="John G" last="Mchutchison">John G. Mchutchison</name>
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<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Br U, Norbert" sort="Br U, Norbert" uniqKey="Br U N" first="Norbert" last="Br U">Norbert Br U</name>
<affiliation wicri:level="2"><nlm:affiliation>James J. Peters Veterans Affairs Medical Center, Bronx, New York; Icahn School of Medicine at Mount Sinai, New York, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>James J. Peters Veterans Affairs Medical Center, Bronx, New York; Icahn School of Medicine at Mount Sinai, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Berg, Thomas" sort="Berg, Thomas" uniqKey="Berg T" first="Thomas" last="Berg">Thomas Berg</name>
<affiliation wicri:level="3"><nlm:affiliation>Medical Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Medical Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
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<author><name sortKey="Agarwal, Kosh" sort="Agarwal, Kosh" uniqKey="Agarwal K" first="Kosh" last="Agarwal">Kosh Agarwal</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Liver Studies, Kings College Hospital, London</wicri:regionArea>
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</placeName>
</affiliation>
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<author><name sortKey="Bhandari, Bal Raj" sort="Bhandari, Bal Raj" uniqKey="Bhandari B" first="Bal Raj" last="Bhandari">Bal Raj Bhandari</name>
<affiliation wicri:level="2"><nlm:affiliation>Gastroenterology and Nutritional Medical Services, Bastrop, Louisiana.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Louisiane</region>
</placeName>
<wicri:cityArea>Gastroenterology and Nutritional Medical Services, Bastrop</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Davis, Mitchell" sort="Davis, Mitchell" uniqKey="Davis M" first="Mitchell" last="Davis">Mitchell Davis</name>
<affiliation wicri:level="2"><nlm:affiliation>Digestive Care, South Florida Center of Gastroenterology, Wellington, Florida.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Digestive Care, South Florida Center of Gastroenterology, Wellington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Feld, Jordan J" sort="Feld, Jordan J" uniqKey="Feld J" first="Jordan J" last="Feld">Jordan J. Feld</name>
<affiliation wicri:level="1"><nlm:affiliation>Toronto Western Hospital Liver Centre, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Toronto Western Hospital Liver Centre, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dore, Gregory J" sort="Dore, Gregory J" uniqKey="Dore G" first="Gregory J" last="Dore">Gregory J. Dore</name>
<affiliation wicri:level="1"><nlm:affiliation>St Vincent's Hospital Sydney, University of New South Wales Sydney, Sydney, New South Wales, Australia; Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>St Vincent's Hospital Sydney, University of New South Wales Sydney, Sydney, New South Wales, Australia; Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stedman, Catherine A M" sort="Stedman, Catherine A M" uniqKey="Stedman C" first="Catherine A M" last="Stedman">Catherine A M. Stedman</name>
<affiliation wicri:level="1"><nlm:affiliation>Christchurch Hospital, University of Otago, Christchurch, New Zealand.</nlm:affiliation>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Christchurch Hospital, University of Otago, Christchurch</wicri:regionArea>
<wicri:noRegion>Christchurch</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thompson, Alexander J" sort="Thompson, Alexander J" uniqKey="Thompson A" first="Alexander J" last="Thompson">Alexander J. Thompson</name>
<affiliation wicri:level="1"><nlm:affiliation>St. Vincent's Hospital, Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>St. Vincent's Hospital, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Asselah, Tarik" sort="Asselah, Tarik" uniqKey="Asselah T" first="Tarik" last="Asselah">Tarik Asselah</name>
<affiliation wicri:level="1"><nlm:affiliation>Hôpital Beaujon, Université Paris Diderot, INSERM UMR 1149, Centre de Recherche sur l'Inflammation, Clichy, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital Beaujon, Université Paris Diderot, INSERM UMR 1149, Centre de Recherche sur l'Inflammation, Clichy</wicri:regionArea>
<wicri:noRegion>Clichy</wicri:noRegion>
<wicri:noRegion>Clichy</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roberts, Stuart K" sort="Roberts, Stuart K" uniqKey="Roberts S" first="Stuart K" last="Roberts">Stuart K. Roberts</name>
<affiliation wicri:level="1"><nlm:affiliation>Alfred Hospital, Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Alfred Hospital, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Foster, Graham R" sort="Foster, Graham R" uniqKey="Foster G" first="Graham R" last="Foster">Graham R. Foster</name>
<affiliation wicri:level="3"><nlm:affiliation>Royal London Hospital, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal London Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir in Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials.</title>
<author><name sortKey="Jacobson, Ira M" sort="Jacobson, Ira M" uniqKey="Jacobson I" first="Ira M" last="Jacobson">Ira M. Jacobson</name>
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<author><name sortKey="Lawitz, Eric" sort="Lawitz, Eric" uniqKey="Lawitz E" first="Eric" last="Lawitz">Eric Lawitz</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
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</affiliation>
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<author><name sortKey="Gane, Edward J" sort="Gane, Edward J" uniqKey="Gane E" first="Edward J" last="Gane">Edward J. Gane</name>
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<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Willems, Bernard E" sort="Willems, Bernard E" uniqKey="Willems B" first="Bernard E" last="Willems">Bernard E. Willems</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre Hospitalier de l'Université de Montréal, Montréal, Québec</wicri:regionArea>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruane, Peter J" sort="Ruane, Peter J" uniqKey="Ruane P" first="Peter J" last="Ruane">Peter J. Ruane</name>
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<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Ruane Medical and Liver Health Institute, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nahass, Ronald G" sort="Nahass, Ronald G" uniqKey="Nahass R" first="Ronald G" last="Nahass">Ronald G. Nahass</name>
<affiliation wicri:level="2"><nlm:affiliation>ID Care, Hillsborough, New Jersey.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>ID Care, Hillsborough</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Borgia, Sergio M" sort="Borgia, Sergio M" uniqKey="Borgia S" first="Sergio M" last="Borgia">Sergio M. Borgia</name>
<affiliation wicri:level="1"><nlm:affiliation>William Osler Health System, Brampton Civic Hospital, Brampton, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>William Osler Health System, Brampton Civic Hospital, Brampton, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shafran, Stephen D" sort="Shafran, Stephen D" uniqKey="Shafran S" first="Stephen D" last="Shafran">Stephen D. Shafran</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of Alberta, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Workowski, Kimberly A" sort="Workowski, Kimberly A" uniqKey="Workowski K" first="Kimberly A" last="Workowski">Kimberly A. Workowski</name>
<affiliation wicri:level="1"><nlm:affiliation>Emory University, Atlanta, Georgia.</nlm:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Emory University, Atlanta</wicri:regionArea>
<wicri:noRegion>Atlanta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pearlman, Brian" sort="Pearlman, Brian" uniqKey="Pearlman B" first="Brian" last="Pearlman">Brian Pearlman</name>
<affiliation wicri:level="1"><nlm:affiliation>Atlanta Medical Center, Atlanta, Georgia.</nlm:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Atlanta Medical Center, Atlanta</wicri:regionArea>
<wicri:noRegion>Atlanta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hyland, Robert H" sort="Hyland, Robert H" uniqKey="Hyland R" first="Robert H" last="Hyland">Robert H. Hyland</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Stamm, Luisa M" sort="Stamm, Luisa M" uniqKey="Stamm L" first="Luisa M" last="Stamm">Luisa M. Stamm</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Svarovskaia, Evguenia" sort="Svarovskaia, Evguenia" uniqKey="Svarovskaia E" first="Evguenia" last="Svarovskaia">Evguenia Svarovskaia</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dvory Sobol, Hadas" sort="Dvory Sobol, Hadas" uniqKey="Dvory Sobol H" first="Hadas" last="Dvory-Sobol">Hadas Dvory-Sobol</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zhu, Yanni" sort="Zhu, Yanni" uniqKey="Zhu Y" first="Yanni" last="Zhu">Yanni Zhu</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Subramanian, G Mani" sort="Subramanian, G Mani" uniqKey="Subramanian G" first="G Mani" last="Subramanian">G Mani Subramanian</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Brainard, Diana M" sort="Brainard, Diana M" uniqKey="Brainard D" first="Diana M" last="Brainard">Diana M. Brainard</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mchutchison, John G" sort="Mchutchison, John G" uniqKey="Mchutchison J" first="John G" last="Mchutchison">John G. Mchutchison</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Inc, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Inc, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Br U, Norbert" sort="Br U, Norbert" uniqKey="Br U N" first="Norbert" last="Br U">Norbert Br U</name>
<affiliation wicri:level="2"><nlm:affiliation>James J. Peters Veterans Affairs Medical Center, Bronx, New York; Icahn School of Medicine at Mount Sinai, New York, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>James J. Peters Veterans Affairs Medical Center, Bronx, New York; Icahn School of Medicine at Mount Sinai, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Berg, Thomas" sort="Berg, Thomas" uniqKey="Berg T" first="Thomas" last="Berg">Thomas Berg</name>
<affiliation wicri:level="3"><nlm:affiliation>Medical Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Medical Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Agarwal, Kosh" sort="Agarwal, Kosh" uniqKey="Agarwal K" first="Kosh" last="Agarwal">Kosh Agarwal</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Liver Studies, Kings College Hospital, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Liver Studies, Kings College Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bhandari, Bal Raj" sort="Bhandari, Bal Raj" uniqKey="Bhandari B" first="Bal Raj" last="Bhandari">Bal Raj Bhandari</name>
<affiliation wicri:level="2"><nlm:affiliation>Gastroenterology and Nutritional Medical Services, Bastrop, Louisiana.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Louisiane</region>
</placeName>
<wicri:cityArea>Gastroenterology and Nutritional Medical Services, Bastrop</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Davis, Mitchell" sort="Davis, Mitchell" uniqKey="Davis M" first="Mitchell" last="Davis">Mitchell Davis</name>
<affiliation wicri:level="2"><nlm:affiliation>Digestive Care, South Florida Center of Gastroenterology, Wellington, Florida.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Digestive Care, South Florida Center of Gastroenterology, Wellington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Feld, Jordan J" sort="Feld, Jordan J" uniqKey="Feld J" first="Jordan J" last="Feld">Jordan J. Feld</name>
<affiliation wicri:level="1"><nlm:affiliation>Toronto Western Hospital Liver Centre, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Toronto Western Hospital Liver Centre, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dore, Gregory J" sort="Dore, Gregory J" uniqKey="Dore G" first="Gregory J" last="Dore">Gregory J. Dore</name>
<affiliation wicri:level="1"><nlm:affiliation>St Vincent's Hospital Sydney, University of New South Wales Sydney, Sydney, New South Wales, Australia; Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>St Vincent's Hospital Sydney, University of New South Wales Sydney, Sydney, New South Wales, Australia; Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stedman, Catherine A M" sort="Stedman, Catherine A M" uniqKey="Stedman C" first="Catherine A M" last="Stedman">Catherine A M. Stedman</name>
<affiliation wicri:level="1"><nlm:affiliation>Christchurch Hospital, University of Otago, Christchurch, New Zealand.</nlm:affiliation>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Christchurch Hospital, University of Otago, Christchurch</wicri:regionArea>
<wicri:noRegion>Christchurch</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thompson, Alexander J" sort="Thompson, Alexander J" uniqKey="Thompson A" first="Alexander J" last="Thompson">Alexander J. Thompson</name>
<affiliation wicri:level="1"><nlm:affiliation>St. Vincent's Hospital, Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>St. Vincent's Hospital, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Asselah, Tarik" sort="Asselah, Tarik" uniqKey="Asselah T" first="Tarik" last="Asselah">Tarik Asselah</name>
<affiliation wicri:level="1"><nlm:affiliation>Hôpital Beaujon, Université Paris Diderot, INSERM UMR 1149, Centre de Recherche sur l'Inflammation, Clichy, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital Beaujon, Université Paris Diderot, INSERM UMR 1149, Centre de Recherche sur l'Inflammation, Clichy</wicri:regionArea>
<wicri:noRegion>Clichy</wicri:noRegion>
<wicri:noRegion>Clichy</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roberts, Stuart K" sort="Roberts, Stuart K" uniqKey="Roberts S" first="Stuart K" last="Roberts">Stuart K. Roberts</name>
<affiliation wicri:level="1"><nlm:affiliation>Alfred Hospital, Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Alfred Hospital, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Foster, Graham R" sort="Foster, Graham R" uniqKey="Foster G" first="Graham R" last="Foster">Graham R. Foster</name>
<affiliation wicri:level="3"><nlm:affiliation>Royal London Hospital, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal London Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Gastroenterology</title>
<idno type="eISSN">1528-0012</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antiviral Agents (administration & dosage)</term>
<term>Antiviral Agents (adverse effects)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Carbamates (administration & dosage)</term>
<term>Carbamates (adverse effects)</term>
<term>Carbamates (therapeutic use)</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Hepatitis C, Chronic (drug therapy)</term>
<term>Heterocyclic Compounds, 4 or More Rings (administration & dosage)</term>
<term>Heterocyclic Compounds, 4 or More Rings (adverse effects)</term>
<term>Heterocyclic Compounds, 4 or More Rings (therapeutic use)</term>
<term>Humans</term>
<term>Macrocyclic Compounds (administration & dosage)</term>
<term>Macrocyclic Compounds (adverse effects)</term>
<term>Macrocyclic Compounds (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Sofosbuvir (administration & dosage)</term>
<term>Sofosbuvir (adverse effects)</term>
<term>Sofosbuvir (therapeutic use)</term>
<term>Sulfonamides (administration & dosage)</term>
<term>Sulfonamides (adverse effects)</term>
<term>Sulfonamides (therapeutic use)</term>
<term>Sustained Virologic Response</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Antiviraux (administration et posologie)</term>
<term>Antiviraux (effets indésirables)</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Association de médicaments</term>
<term>Carbamates (administration et posologie)</term>
<term>Carbamates (effets indésirables)</term>
<term>Carbamates (usage thérapeutique)</term>
<term>Composés hétérocycliques avec 4 noyaux ou plus (administration et posologie)</term>
<term>Composés hétérocycliques avec 4 noyaux ou plus (effets indésirables)</term>
<term>Composés hétérocycliques avec 4 noyaux ou plus (usage thérapeutique)</term>
<term>Composés macrocycliques (administration et posologie)</term>
<term>Composés macrocycliques (effets indésirables)</term>
<term>Composés macrocycliques (usage thérapeutique)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hépatite C chronique (traitement médicamenteux)</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Réponse virologique soutenue</term>
<term>Sofosbuvir (administration et posologie)</term>
<term>Sofosbuvir (effets indésirables)</term>
<term>Sofosbuvir (usage thérapeutique)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Sulfonamides (administration et posologie)</term>
<term>Sulfonamides (effets indésirables)</term>
<term>Sulfonamides (usage thérapeutique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiviral Agents</term>
<term>Carbamates</term>
<term>Heterocyclic Compounds, 4 or More Rings</term>
<term>Macrocyclic Compounds</term>
<term>Sofosbuvir</term>
<term>Sulfonamides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiviral Agents</term>
<term>Carbamates</term>
<term>Heterocyclic Compounds, 4 or More Rings</term>
<term>Macrocyclic Compounds</term>
<term>Sofosbuvir</term>
<term>Sulfonamides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
<term>Carbamates</term>
<term>Heterocyclic Compounds, 4 or More Rings</term>
<term>Macrocyclic Compounds</term>
<term>Sofosbuvir</term>
<term>Sulfonamides</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antiviraux</term>
<term>Carbamates</term>
<term>Composés hétérocycliques avec 4 noyaux ou plus</term>
<term>Composés macrocycliques</term>
<term>Sofosbuvir</term>
<term>Sulfonamides</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hepatitis C, Chronic</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antiviraux</term>
<term>Carbamates</term>
<term>Composés hétérocycliques avec 4 noyaux ou plus</term>
<term>Composés macrocycliques</term>
<term>Sofosbuvir</term>
<term>Sulfonamides</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hépatite C chronique</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term>
<term>Carbamates</term>
<term>Composés hétérocycliques avec 4 noyaux ou plus</term>
<term>Composés macrocycliques</term>
<term>Sofosbuvir</term>
<term>Sulfonamides</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Sustained Virologic Response</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Association de médicaments</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Réponse virologique soutenue</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Patients with chronic hepatitis C virus (HCV) infection have high rates of sustained virologic response (SVR) after 12 weeks of treatment with the nucleotide polymerase inhibitor sofosbuvir combined with the NS5A inhibitor velpatasvir. We assessed the efficacy of 8 weeks of treatment with sofosbuvir and velpatasvir plus the pangenotypic NS3/4A protease inhibitor voxilaprevir (sofosbuvir-velpatasvir-voxilaprevir).</div>
</front>
</TEI>
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<li>Australie</li>
<li>Canada</li>
<li>France</li>
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<li>Royaume-Uni</li>
<li>États-Unis</li>
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<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Jacobson, Ira M" sort="Jacobson, Ira M" uniqKey="Jacobson I" first="Ira M" last="Jacobson">Ira M. Jacobson</name>
</region>
<name sortKey="Bhandari, Bal Raj" sort="Bhandari, Bal Raj" uniqKey="Bhandari B" first="Bal Raj" last="Bhandari">Bal Raj Bhandari</name>
<name sortKey="Br U, Norbert" sort="Br U, Norbert" uniqKey="Br U N" first="Norbert" last="Br U">Norbert Br U</name>
<name sortKey="Brainard, Diana M" sort="Brainard, Diana M" uniqKey="Brainard D" first="Diana M" last="Brainard">Diana M. Brainard</name>
<name sortKey="Davis, Mitchell" sort="Davis, Mitchell" uniqKey="Davis M" first="Mitchell" last="Davis">Mitchell Davis</name>
<name sortKey="Dvory Sobol, Hadas" sort="Dvory Sobol, Hadas" uniqKey="Dvory Sobol H" first="Hadas" last="Dvory-Sobol">Hadas Dvory-Sobol</name>
<name sortKey="Hyland, Robert H" sort="Hyland, Robert H" uniqKey="Hyland R" first="Robert H" last="Hyland">Robert H. Hyland</name>
<name sortKey="Lawitz, Eric" sort="Lawitz, Eric" uniqKey="Lawitz E" first="Eric" last="Lawitz">Eric Lawitz</name>
<name sortKey="Mchutchison, John G" sort="Mchutchison, John G" uniqKey="Mchutchison J" first="John G" last="Mchutchison">John G. Mchutchison</name>
<name sortKey="Nahass, Ronald G" sort="Nahass, Ronald G" uniqKey="Nahass R" first="Ronald G" last="Nahass">Ronald G. Nahass</name>
<name sortKey="Ruane, Peter J" sort="Ruane, Peter J" uniqKey="Ruane P" first="Peter J" last="Ruane">Peter J. Ruane</name>
<name sortKey="Stamm, Luisa M" sort="Stamm, Luisa M" uniqKey="Stamm L" first="Luisa M" last="Stamm">Luisa M. Stamm</name>
<name sortKey="Subramanian, G Mani" sort="Subramanian, G Mani" uniqKey="Subramanian G" first="G Mani" last="Subramanian">G Mani Subramanian</name>
<name sortKey="Svarovskaia, Evguenia" sort="Svarovskaia, Evguenia" uniqKey="Svarovskaia E" first="Evguenia" last="Svarovskaia">Evguenia Svarovskaia</name>
<name sortKey="Zhu, Yanni" sort="Zhu, Yanni" uniqKey="Zhu Y" first="Yanni" last="Zhu">Yanni Zhu</name>
</country>
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</noRegion>
<name sortKey="Stedman, Catherine A M" sort="Stedman, Catherine A M" uniqKey="Stedman C" first="Catherine A M" last="Stedman">Catherine A M. Stedman</name>
</country>
<country name="Canada"><noRegion><name sortKey="Willems, Bernard E" sort="Willems, Bernard E" uniqKey="Willems B" first="Bernard E" last="Willems">Bernard E. Willems</name>
</noRegion>
<name sortKey="Borgia, Sergio M" sort="Borgia, Sergio M" uniqKey="Borgia S" first="Sergio M" last="Borgia">Sergio M. Borgia</name>
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<name sortKey="Shafran, Stephen D" sort="Shafran, Stephen D" uniqKey="Shafran S" first="Stephen D" last="Shafran">Stephen D. Shafran</name>
</country>
<country name="Géorgie (pays)"><noRegion><name sortKey="Workowski, Kimberly A" sort="Workowski, Kimberly A" uniqKey="Workowski K" first="Kimberly A" last="Workowski">Kimberly A. Workowski</name>
</noRegion>
<name sortKey="Pearlman, Brian" sort="Pearlman, Brian" uniqKey="Pearlman B" first="Brian" last="Pearlman">Brian Pearlman</name>
</country>
<country name="Allemagne"><region name="Berlin"><name sortKey="Berg, Thomas" sort="Berg, Thomas" uniqKey="Berg T" first="Thomas" last="Berg">Thomas Berg</name>
</region>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Agarwal, Kosh" sort="Agarwal, Kosh" uniqKey="Agarwal K" first="Kosh" last="Agarwal">Kosh Agarwal</name>
</region>
<name sortKey="Foster, Graham R" sort="Foster, Graham R" uniqKey="Foster G" first="Graham R" last="Foster">Graham R. Foster</name>
</country>
<country name="Australie"><noRegion><name sortKey="Dore, Gregory J" sort="Dore, Gregory J" uniqKey="Dore G" first="Gregory J" last="Dore">Gregory J. Dore</name>
</noRegion>
<name sortKey="Roberts, Stuart K" sort="Roberts, Stuart K" uniqKey="Roberts S" first="Stuart K" last="Roberts">Stuart K. Roberts</name>
<name sortKey="Thompson, Alexander J" sort="Thompson, Alexander J" uniqKey="Thompson A" first="Alexander J" last="Thompson">Alexander J. Thompson</name>
</country>
<country name="France"><noRegion><name sortKey="Asselah, Tarik" sort="Asselah, Tarik" uniqKey="Asselah T" first="Tarik" last="Asselah">Tarik Asselah</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D40 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000D40 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:28390869
   |texte=   Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir in Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:28390869" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir in Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials.

Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir in Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
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